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KMID : 1039420150490040325
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Journal of Pathology and Translational Medicine
2015 Volume.49 No. 4 p.325 ~ p.330
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WHO Grade IV Gliofibroma: A Grading Label Denoting Malignancy for an Otherwise Commonly Misinterpreted Neoplasm
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Abril Paola A. Escalante
Salazar Miguel Fdo.
Garcia Nubia L. Lopez
Moya Monica N. Madrazo
Guerra Yadir U. Zamora
Mendoza Yadira Gandhi Mata
Apo Erick Gomez
Macias Laura G. Chavez
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Abstract
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We report a 50-year-old woman with no relevant clinical history who presented with headache and loss of memory. Magnetic resonance imaging showed a left parieto-temporal mass with annular enhancement after contrast media administration, rendering a radiological diagnosis of high-grade astrocytic neoplasm. Tumour sampling was performed but the patient ultimately died as a result of disease. Microscopically, the lesion had areas of glioblastoma mixed with a benign mesenchymal constituent; the former showed hypercellularity, endothelial proliferation, high mitotic activity and necrosis, while the latter showed fascicles of long spindle cells surrounded by collagen and reticulin fibers. With approximately 40 previously reported cases, gliofibroma is a rare neoplasm defined as either glio-desmoplastic or glial/benign mesenchymal. As shown in our case, its prognosis is apparently determined by the degree of anaplasia of the glial component.
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KEYWORD
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Gliofibroma, Bimorphic neoplasm, Desmoplastic glioma, Adult population, Tumour suppressor protein 53
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